Research Interests
- Systems biology; molecular nutrition; genomics; metabolomics; bioinformatics; nutritional programming of adipose tissue; mammary gland development; lipid metabolism; conjugated linoleic acids (CLA); nutritional and physiological genomics; comparative genomics; regulation of milk fat and protein synthesis; nutritional regulation of muscle development.My research program focuses on the study of how nutrition, physiological state and their interaction affect tissue function and metabolic adaptations through alterations in the transcriptome, i.e. mRNA expression profiles. We rely heavily on cutting-edge technologies such as microarrays, DNA sequencing, quantitative RT-PCR, and bioinformatics to generate biologically-meaningful data. The integration of these data sets is at the core of our Systems Biology efforts in Nutritional Sciences. We use large animals as primary models but also perform more fundamental studies with animal tissue cell lines or explant cultures. Through the use of high-throughput techniques and bioinformatics we intend to identify genes that might be associated with susceptibility to immune and metabolic diseases (e.g. hepatic steatosis, mastitis) and also to developing obesity.
Education
- Ph.D., 2001, Virginia Polytechnic Institute and State University, Blacksburg
- M.S., 1997, Virginia Polytechnic Institute and State University, Blacksburg
- B.S., 1995, University of California, Davis
Additional Campus Affiliations
Professor, Animal Sciences
Professor, Nutritional Sciences
Professor, Center for Latin American and Caribbean Studies
Recent Publications
Dong, Y., Gao, W., Liu, K., Lin, C., Usman, M., Loor, J. J., Li, G., Cao, L., Yang, Z., Luo, J., Li, D., Sun, Q., Lei, L., Du, X., Song, Y., Liu, G., & Li, X. (2025). Cullin 3 mitigates nonesterified fatty acid–induced oxidative stress in mammary epithelial cells: Involvement of BCL2/BECN1 and autophagy. Journal of Dairy Science, 108(4), 4163-4179. https://doi.org/10.3168/jds.2024-25879
Huo, Y., Shen, T., Feng, T., Li, M., Zhao, W., Loor, J. J., Aernouts, B., Psifidi, A., & Xu, C. (2025). β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy. Journal of Animal Science and Biotechnology, 16(1), Article 15. Advance online publication. https://doi.org/10.1186/s40104-024-01143-z
Incharoen, T., Charoensook, R., Tartrakoon, W., Numthuam, S., Sunanta, Y., Jimenez, G., & Loor, J. J. (2025). Dietary Bacillus toyonensis BCT-7112T Supplementation Influences Performance, Egg Quality, Ammonia Emission, and Cecal Microbiome in Laying Ducks. Veterinary Sciences, 12(3), Article 259. https://doi.org/10.3390/vetsci12030259
Incharoen, T., Nopparatmaitree, M., Kongkeaw, A., Soisuwan, K., Likittrakulwong, W., Thongnum, A., Norbu, N., Tenzin, J., Supatsaraphokin, N., & Loor, J. J. (2025). Dietary micronized hemp fiber enhances in vitro nutrient digestibility and cecal fermentation, antioxidant enzyme, lysosomal activity, and productivity in finisher broilers reared under thermal stress. Frontiers in Animal Science, 6, Article 1553829. https://doi.org/10.3389/fanim.2025.1553829
Li, M., Zhao, B., Wang, J., Zhang, H., Yang, Y., Song, S., Psifidi, A., Wu, W., Loor, J. J., & Xu, C. (2025). Caveolin 1 in bovine liver is associated with fatty acid–induced lipid accumulation and the endoplasmic reticulum unfolded protein response: Role in fatty liver development. Journal of Dairy Science, 108(1), 1007-1021. https://doi.org/10.3168/jds.2024-25349